Animals were sleep deprived using the modified multiple platform method. It is well known that caffeine and sleep deprivation have opposing effects on learning and memory therefore, this study was undertaken to determine the effects of chronic (4wks) caffeine treatment (0.3g/l in drinking water) on long-term memory deficit associated with 24h sleep deprivation. Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine.Īlhaider IA, Aleisa AM, Tran TT, Alkadhi KA.ĭepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA. I looked around for the caffiene + cAMP study and found this: Ok "Short-Circuit" is not the most scientific term when talking about neuro-chem. This is fine for the normal person at a normal dose of caffeine, but makes things difficult with those who have low levels of norepinephrine, like those with ADHD. It's just that it short circuits the prefrontal cortex, decreasing concentration. * Wandering thoughts inability to sustain a train of thoughtĬAMP isn't a bad thing at all. Possible effects in the central nervous system resemble those associated with delirium, and may include: They are often used in nootropics studies to test if a nootropic drug is powerful enough to *reverse* their negative effects on cognition. You don't ever ever ever want to take anti-cholinergics. Anticholinergics increase concentration.Īhhh. something like an alpha 2 agonist like Guanfacine (Intuniv). I'd much rather find a natural alternative to the ill effects of caffeine. I'm not a big fan of medications, because they are expensive, a complete hassle, and covered in the green slime of pharmaceutical greed. My grandmother drank 6-12oz of coffee every morning and lived to be 93. I enjoy caffeine and will ignore all attempts at convincing me to quit. Therefore, a way to combat caffeine is either with more norepinephrine, less cAMP, or an agonist at the adrenal alpha 2 receptor.
Norepinephrine opens these channels via the adrenal alpha 2 receptor. Increasing cAMP in the PFC like caffeine actually inhibits the PFC from making proper connections. Caffeine is an adenosine blocker which in turn causes an increase in dopamine and norepinephrine. I'm a caffeine addict and have been for years. ( ) After reading that cAMP closes connections in the PFC, I suddenly realized that I have been making my ADHD worse.
It works by activating the Adrenal Alpha 2 receptors in the prefrontal cortex, reversing the effects of cAMP overload. Guanfacine is the amazing blood pressure medication that has been discovered as a powerful element in a synergistic treatment for ADHD.
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